Home Welcome Mission Instrumentation Members Research Program Collaboration Projects Dissemination Links Contact

Home Welcome Mission Instrumentation Members Research Program Collaboration Projects Dissemination Links Contact

We succeeded to establish the laboratory of Process Analytical Technology (VAN STADEN PATLAB) as a laboratory of excellence in Bucharest, Romania with international standards that is recognized not only in Europe, but also among the worldwide scientific community. (For more details please look at www.patlab.ro/ENG/EUROPASS-CV-VANSTADEN-JF.pdf and http://www.patlab.ro/ENG/Europass-CV-2017_10-RIVanStaden-EN.pdf under members/scientists). With an H-index = 31 for Prof Dr J F (Koos) van Staden and H-index = 26 for Prof Dr R I (Raluca) Stefan-van Staden this is also evident from the research output (dissemination) of the laboratory given below:-

PEER REVIEWED INTERNATIONAL PUBLICATIONS

2008

1.        Sequential injection analysis utilizing amperometric biosensors as detectors for simultaneous determination of L- and D-pipecolic acid.

           R.I. Stefan-van Staden, R. M. Nejem, J.F. van Staden and H.Y. Aboul-Enein.

           Instrumentation Science and Technology, 36 (5) (2008) 355 - 368.

2.        Determination of (+)-3,3’,5,5’-tetraiodo (L-T4) in serum and in pharmaceutical formulations using a sequential injection analysis/immunosensor system.

           R.I. Stefan-van Staden, J.F. van Staden, H.Y. Aboul-Enein, M. C. Mirica, I. Balcu and N. Mirica.

           Journal of Immunoassay and Immunochemistry, 29 (4) (2008) 348 - 355.

2009

1.        Enantioanalysis of L-proline using C60 as chiral selectors.

           R.I. Stefan-van Staden.

           Analytical Letters, 42 (2) (2009) 323-329.

2.        Amperometric immunosensors for the determination of 2’,3’-dideoxyinosine

           R.I. Stefan-van Staden and K.I. Ozoemena

           Analytical Letters, 42 (4) (2009) 758-763.

3.        Enantioanalysis of S-Ketoprofen using enantioselective, potentiometric membrane electrodes.

           R.I. Stefan-van Staden, N. S. Nhlapo, J.F. van Staden and H.Y. Aboul-Enein.

           Analytical Letters, 42 (5) (2009) 764 - 774.

4.        Macrocyclic antibiotics as chiral selectors in the design of enantioselective, potentiometric membrane electrodes for the determination of S-flurbiprofen.

           R.I. Stefan-van Staden, J.F. van Staden and H.Y. Aboul-Enein.

           Analytical and Bioanalytical Chemistry, 394 (3) (2009) 821-826.

5.        Utilization of an enantioselective surface plasmon resonance electrode for the

           selection of the best C70 fullerene as chiral selector for the enantioanalysis of L -cysteine

           R.I. Stefan-van Staden, L. Holo

           Preparative Biochemistry and Biotechnology, 39 (2) (2009) 142-146.

6.        Metallophthalocyanine based carbon paste electrodes for the determination of 2’,3’-dideoxyinosine

           K.I. Ozoemena, R.I. Stefan-van Staden and T. Nyokong

           Electroanalysis, 21 (14) (2009) 1651-1654.

7.        Enantioselective determination of R-Clenbuterol using an enantioselective, potentiometric membrane electrode based on a β-cyclodextrin derivative.

           R.I. Stefan-van Staden, L. Holo, B Moeketsi, J.F. van Staden and H.Y. Aboul-Enein.

           Instrumentation Science and Technology, 37 (2) (2009) 189 - 196.

8.        Determination of (S)-(+)-Ibuprofen using enantioselective, potentiometric membrane electrodes based on a Macrocyclic Antibiotics.

           R.I. Stefan-van Staden, T. Mashile, K. C. Mathabathe and J.F. van Staden.

           Instrumentation Science and Technology, 37 (2) (2009) 197 - 203.

9.        Enantioanalysis of butaclamol using enantioselective, potentiometric electrodes.

           R.I. Stefan-van Staden, R.G. Bokretsion, J.F. van Staden and H.Y. Aboul-Enein.

           Analytical Letters, 42 (8) (2009) 1111 - 1118.

10.      Maltodextrins as chiral selectors in biomedical enantioanalysis. A minireview.

           R.I. Stefan-van Staden, J.F. van Staden, H.Y. Aboul-Enein, M.C. Mirica, M. Iorga and I. Balcu

           The Open Chem Biomed Meth J , 2 (2009) 107-110.

2010

1.        Application of porphyrins in flow-injection analysis. A Review.

           J.F. van Staden and R.I. Stefan-van Staden.

           Talanta, 80 (5) (2010) 1598 – 1605.

2.        Enantioanalysis of S-deprenyl based on its interaction with C60 fullerene derivatives.

           R.I. Stefan-van Staden.

           Electrochimica Acta, 55 (5) (2010) 1772 - 1777.

3.        Enantioanalysis of S-Ibuprofen using [5-6] Fullerene-C70 and diethyl (1,2-methanofullerene C70)-71-71-dicarboxylate.

           R.I. Stefan-van Staden.

           Analytical Methods, 2 (1) (2010) 37 – 40.

4.        Diamond paste based electrodes for the determination of  sildenafil citrate (viagra).

           R.I. Stefan-van Staden, J.F. van Staden and H.Y. Aboul-Enein.

           Journal of Solid State Electrochemistry, 14 (6) (2010) 997 – 1000

5.        Enantioanalysis of R-deprenyl based on its molecular interaction with C70 fullerenes.

           R.I. Stefan-van Staden

           Talanta, 81 (3) (2010) 865 - 870

6.        Determination of free L-T4 and free L-T3 from blood using the immunosensors/sequential injection analysis system.

           R.I. Stefan, J.F. van Staden, H.Y. Aboul-Enein, I. Balcu, M.C. Mirica, G.L. Radu,

           Analytical Letters, 43 (7-8) (2010) 1119 – 1125.

7.        Micro- and nanosensors. Recent developments and features. A minireview.

           R.I. Stefan-van Staden, J.F. van Staden, S.C. Balasoiu, O.R. Vasile

           Analytical Letters, 43 (7-8) (2010) 1111 - 1118.

8.        Simultaneous determination of L- and D-T4 using a sequential injection  analysis/sensors system.

           R.I. Stefan-van Staden, J.F. van Staden, H.Y. Aboul-Enein, I. Balcu, M.C. Mirica

           Combinatorial Chemistry & High Throughput Screening, 13 (6) (2010) 497 - 501.

9.        Enantioanalysis of (-)butaclamol using vancomycin and teicoplanin as chiral selectors.

           R.I. Stefan-van Staden, N.S. Nhlapo, J.F. van Staden, H.Y. Aboul-Enein.

           Combinatorial Chemistry & High Throughput Screening, 13 (8) (2010) 690 – 693.

10.      Wireless electrochemical sensors. A tool for process control. The past, present and the future. A mini-review.

           J.F. van Staden, R.I. Stefan-van Staden, S.C. Balasoiu.

           Critical Reviews in Analytical Chemistry, 40 (4) (2010) 226 -233..

11.      Enantioanalysis of D-histidine based on its interaction with [5-6] fullerene-C70 and diethyl (1,2-methanofullerene C70)-71-71-dicarboxylate.

           R.I. Stefan-van Staden.

           New Journal of Chemistry, 34 (6) (2010) 1141 – 1147.

12.      Diamond paste based electrodes for the determination of Ag(I).

           R.I. Stefan-van Staden, S. G. Bairu and J. F. van Staden.

           Analytical Methods, 2 (6) (2010) 250 - 252.

13.      Carbon and diamond paste microelectrodes based on Mn(III) porphyrins for the determination of dopamine.

           S. C. Balasoiu, R.I. Stefan-van Staden, J. F. van Staden, S. Pruneanu and G. L. Radu.

           Analytica Chimica Acta, 668 (2) (2010) 201 - 207.

 

2011

 

1.         Enantiosel ective potentiometric membrane electrodes based on antibiotics for the determination of

            L-  and D-Glyceric Acids.

            R.I. Stefan-van Staden, R. M. Nejem, J.F. van Staden and H.Y. Aboul-Enein

            Current Pharmaceutical Analysis, 7 (4) (2011) 253-257.

 

2.         Enantioanalysis of L-histidine using enantioselective, potentiometric membrane electrodes based on maltodextrins

            R.I. Stefan-van Staden, L. Holo

            Anal.Lett.,44 (6) (2011) 968-975.

 

3.         Cyclodextrins based enantioselective, potentiometric membrane electrodes (EPME) and their

            applications for enantioanalysis of L-Cysteine in urine.

            R.I. Stefan-van Staden, L. Holo and J.F. van Staden

            Current Pharmaceutical Analysis, 7 (4) (2011) 258-261.

 

4.         Disposable stochastic dot sensors for the assay of ascorbic acid in pharmaceutical samples, beverages and biological fluids.

            R.I. Stefan-van Staden, J.F. van Staden and S.C. Balasoiu

           Analytical Letters, 43 (13) (2011) 2280-2286.

 

5.         Amperometric dot-sensors based on Zinc porphyrins for the Sildenafil citrate determination.

            S.C. Balasoiu, R.I. Stefan-van Staden, J.F. van Staden, R.M. Ion, G.L. Radu and H.Y. Aboul-Enein

            Electrochimica Acta, 58 (1) (2011) 290-295.

 

6.         Enantioselective, potentiometric membrane electrodes based on antibiotics for the determination of L- and D-glyceric acids.

            R.I. Stefan-van Staden, R.M. Nejem, J.F. van Staden and H.Y. Aboul-Enein

            International Journal of Electrochemistry, Volume 2011, Article ID427238, 4pg,doi:10.4061/2011/427238.

2012

282.     Determination of L- and D-Fucose Using Amperometric Electrodes Based on  Diamond Paste.

            R.I. Stefan-van Staden, R. M. Nejem, J.F. van Staden and H.Y. Aboul-Enein

            Analyst, 137(4) (2012) 903 - 909.

283.     Amperometric biosensor based on diamond paste for the enantioanalysis of l-lysine.

            R.I. Stefan-van Staden, R. M. Nejem, J.F. van Staden and H.Y. Aboul-Enein

            Biosensors and Bioelectronics, 35(2) (2012) 439-442.

284.     Microelectrodes based on porphyrins for the determination of ascorbic acid in  pharmaceutical samples and beverages.

            R.I. Stefan-van Staden, S.C. Balasoiu, J.F. van Staden and G.L. Radu.

            Journal of Porphyrins and Phthalocyanines, 16(7-8), (2012), 809-816.

 

285.     Flow-injection analysis systems with different detection devices and other related  techniques for the in vivo and in vitro determination of

            dopamine as neurotransmitter. A review.

            J.F. van Staden and R.I. Stefan-van Staden.

            Talanta, 102 (2012) 34-43. http://dx.doi.org/10.1016/j.talanta.2012.05.017

286.      Electroanalysis of oseltamivir phosphate using new microelectrodes based on zinc complexes with porphyrins and phthalocyanines.

             S.Pop, R.I. Stefan-van Staden, J.F. van Staden, H.Y. Aboul-Enein, R.M. Ion, Z. Aydoğmuş

            Journal of the Electrochemical Society, 159(9), (2012), B789-B793.

287.      Stochastic dot microsensors for the assay of dopamine in pharmaceutical samples and  biological fluids

             R.I. Stefan-van Staden, S.C. Balasoiu, J.F. van Staden

             Journal of the Electrochemical Society, 159(12), (2012), B839-B844. doi:10.1149/2.058212jes

2013

288.      Enantioanalysis of pipecolic acid with stochastic and potentiometric microsensors

             R.I. Stefan-van Staden, I. Moldoveanu, D.F. Sava, C. Kapnissi-Christodoulou,

             J.F. van Staden

             Chirality, 55(2), (2013), 114-118. DOI: 10.1002/chir.22119

289.      Inulins as new electroactive materials for enantioanalysis of chiral drugs

             R.I. Stefan-van Staden, S.C. Balasoiu, G. Bazylak, J.F. van Staden, H.Y. Aboul-Enein, G.L. Radu

             Journal of the Electrochemical Society, 160(10) (2013) B192-B195.

290.      Quinine, quinidine and their tert-butyl carbomylated derivatives as new chiral selectors in the potentiometric, enantioselective membrane electrodes design.

             Their application for the assay of S and R enantiomers of  dinitrobenzene leucine

              R.I. Stefan-van Staden, J.F. van Staden

             Journal of the Electrochemical Society, 160(10) (2013) B196-B200.

 291.     Theoretical considerations regarding the aromaticity of ∆3-heterobenzenes containing 15-group elements.

              R. Pop, M. Andoni, J.F. van Staden, I. Pausescu, M. Medeleanu

              Digest Journal of Nanomaterials and Biostructures, 8(4) (2013) 2207-2218.

292.      New tool for screening of whole blood for early detection of breast cancer antigen (CA153)

             R.I. Stefan-van Staden, J.F. van Staden

             Journal of Modern Medicinal Chemistry, 1(2) (2013) 86-91.

293.      Enantioselective, potentiometric membrane electrodes based on cyclodextrines for the assay of glyceric acid in urine samples

             R.I. Stefan-van Staden, R.M. Nejem, J.F. van Staden

             Revue Roumaine de Chimie, 58(7-8) (2013) 659-665.

2014

294.      Graphene based dot microsensors used for the screening of urine for adenine, guanine and epinephrine

             Jacobus Frederick van Staden, Ramona Georgescu, Raluca-Ioana Stefan-van Staden and Ioan Calinescu

             Journal of the Electrochemical Society, 161(2), (2014), B3014-B3022.

295.       Influence of the physical immobilization of dsDNA on the carbon based matrices of electrochemical sensors

              L.A. Gugoasa, R.I. Stefan-van Staden, A.A. Ciucu, J.F. van Staden

              Current Pharmaceutical Analysis, 10(1) (2014) 20-29.

296.       Influence of sulfate and nitrate uptake from aqueous solutions on surface exchange in Purolite A-520E resin.

              Daniela-Simina Stefan, Jacobus Frederick van Staden, Eugeniu Vasile, Otilia-Ruxandra Vasile and Madelene Dancila

              Comptes Rendus Chimie, 17(7-8) (2014) 738-745.

297.      Evaluation of amperometric dot microsensors for the analysis of serotonin in urine samples

             J.F. van Staden, R. Georgescu, R.I. Stefan-van Staden, I. Calinescu

             Journal of the Electrochemical Society, 161(4), (2014), B49-B54.

 

298.       Pattern recognition of neurotransmitters using multimode sensing

              R.I. Stefan-van Staden, I. Moldoveanu, J.F. van Staden

             Journal of Neuroscience Methods, 229, (2014) 1-7.

299.       A genetic screening test for obesity based on stochastic sensing

              R.I. Stefan-van Staden, L.A. Gugoasa, J.F. van Staden, O.C. Rusu

             Journal of the Electrochemical Society, 161(9), (2014) B167-B170.

300.      Challenges in Enantioanalysis of Fucose Using Stochastic and Potentiometric Microsensors

              I. Moldoveanu, R.I. Stefan-van Staden, C.P. Kapnissi-Cristodoulou, J.F. van Staden, H.Y. Aboul-Enein

              Sensing and Biosensing Research, 1, (2014) 1-7.

301.       Screening tools for neuron specific enolase

              R.I. Stefan-van Staden, I.R. Comnea, J.F. van Staden, C. Stanciu Gavan

              RSC Advances, 4(50), (2014) 26383-26388.

2015

302.      Immunosensors in clinical and environmental analysis

             R.G. Bokretsion, R.I. Stefan-van Staden, J.F. van Staden H.Y. Aboul-Enein

             Critical Reviews in Analytical Chemistry, 45(1) (2015) 2-31.

303.      Platform based on microsensors used for the screening of HER-1 in peritoneal fluid

             I. Moldoveanu, R.I. Stefan-van Staden, J.F. van Staden, C. Stanciu-Gavan, C. Savlovschi

             Revue Roumaine de Chimie, 60(5-6) (2015) 447-451.

304.      Design of potentiometric sensors based on Interaction of cyclodextrins with the enantiomer of interest.

             R.I. Stefan-van Staden, R.G. Bokretsion, J.F. van Staden, H.Y. Aboul-Enein

             Current Drug Therapy, 9(4), (2015) 250-255.

305.      Detection of folic acid from orange juice using amperometric dot microsensors based on graphite and graphene

             R. Georgescu, J.F. van Staden, R.I. Stefan-van Staden

             Revue Roumaine de Chimie, 60(5-6) (2015) 461-466.

306.      Evaluation of Amperometric Dot Microsensors for the Analysis of Folic Acid in Pharmaceutical Tablets and Urine Samples

             R. Georgescu, J.F. van Staden, R.I. Stefan-van Staden, C. Boscornea

             Journal of Porphyrins and Phthalocyanines, 19(5) (2015) 679-687.

307.      Application of phthalocyanines in flow- and sequential-injection analysis and microfluidics systems: A review

             J.F. van Staden.

             Talanta, 139 (2015) 75-88.

308.      Comparison of fluorescein and potassium permanganate in fast low cost screening methods for determination of folic acid in pharmaceutical tablets

             R. Georgescu, J.F. van Staden.

             Revue Roumaine de Chimie, 60(5-6) (2015) 563-569.

309.      Analytical continuous flow systems. Where two worlds collide! From gravimetry and test  tubes to flow systems to FIA to SIA to PAT and from Orsat to control room to PAT to TAP.

             J.F. van Staden.

             Revue Roumaine de Chimie, 60(5-6) (2015) 403-414.

310.      Nitrogen-Containing Coronenes: Theoretical Evaluation of the Influence of Aza- substitution on their Aromaticity

             Raluca Pop, Jacobus van Staden, Mircea Diudea.

             Zeitschrift für Naturforschung A, A JOURNAL OF PHYSICAL SCIENCES 70(3) (2015) 171-175

311.      Ionic liquids for the molecular enantiorecognition of free L-T3, L-T4 and D-T4

             Raluca-Ioana Stefan-van Staden, Grigorina Mitrofan, Ionela Raluca Comnea-Stancu, Jacobus Frederick van Staden, Constantina Kapnissi-Christodoulou and Hassan Y. Aboul-Enein

             RSC Advances, 5(92), (2015) 75451-75457. DOI: 10.1039/C5RA14635F

312.      Carbon Modified Paper Based Sensors

             Raluca-Ioana Stefan-van Staden, Iuliana Moldoveanu, Carmen Cristina Surdu-Bob, Marius Badulescu and Jacobus Frederick van Staden

             Journal of the Electrochemical Society, 162(14), (2015) B360-B362.

313.      Fast Screening of Whole Blood Samples and Pharmaceutical Compounds for Enantiorecognition of Free L-T3, L-T4, and D-T4

             Grigorina Mitrofan, Raluca-Ioana Stefan-van Staden, Ionela Raluca Comnea-Stancu, Jacobus Frederick van Staden, Grzegorz Bazylak, Constantina P. Kapnissi-Christodoulou and Hassan Y. Aboul-Enein

             Chirality, 27(12) (2015) 973-978. | DOI: 10.1002/chir.22537

2016

314.      Stochastic sensors based on maltodextrins for screening of whole blood for neuron specific enolase, carcinoembryonic antigen and epidermal growth factor receptor.

             Ionela Raluca Comnea-Stancu, Raluca-Ioana Stefan-van Staden, Jacobus Frederick van Staden, Camelia Stanciu-Gavan

             Mycrosystem Technologies, 22(1) (2016) 25-29.

315.      New platforms for fast assessment of levels of testosterone, dihydrotestosterone and estradiol in children’s saliva

             L.A. Gugoasa, R.I. Stefan-van Staden, J.F. van Staden, B. Calenic, J. Legler

             Analytical Letters, 49(2) (2016) 335-341.

316.      Theoretical Studies Regarding the Aromaticity of Some Non-Planar Circulenes

             Raluca Pop; Mihai Medeleanu; Jacobus Frederick van Staden; Mircea Diudea,.

             Zeitschrift für Physikalische Chemie, 230(2) (2016) 285-296.

317.      Determination of Dopamine using the Alkaline Luminol-Hydrogen Peroxide System for Sequential Injection - Zone Fluidics Analysis

             Jacobus (Koos) Frederick van Staden and Ramona State

             Analytical Letters, 49(17) (2016) 2783-2792.

2017

318.      A new potentiometric sensor for the assay of P53 in blood samples

             Ahmed Jassim Muklive Al-Ogaidi, Raluca-Ioana Stefan van Staden, Livia Alexandra Gugoasa, Jacobus Frederick van Staden, Hülya Yanik, Meltem Goksel, Mahmut Durmus

             U.P.B. Sci. Bull., Series B, 79(2) (2017) 113-120.

319.      Nanostructured Materials Detect Dopamine in Biological Fluids.

     Raluca-Ioana Stefan-van Staden, Liliana-Roxana Balahura, Alexandra Oprisanu-Vulpe,

     Livia Alexandra Gugoasa, Jacobus F. van Staden, Eleonora-Mihaela Ungureanu,

     Crina Socaci, and Alin-Sebastian Porav

     Journal of the Electrochemical Society, 164 (12) (2017) B561-B566

320.      Molecular recognition of colon cancer biomarkers: P53, KRAS and CEA in whole blood samples

             Ahmed Jassim Muklive Al-Ogaidi, Raluca-Ioana Stefan van Staden, Livia Alexandra Gugoasa, Jacobus Frederick van Staden, Camelia Stanciu-Gavan, Marcela C Rosu, Stela Pruneanu

             Journal of The Electrochemical Society, 164(9) (2017) B443-B447.

 

2018

321.      Determination of Tryptophan in Pharmaceutical Formulations using a Sequential Injection - Zone Fluidic - Chemiluminescence Tubular Reactor.

             Ramona Georgescu-State and Jacobus (Koos) Frederick van Staden

             Analytical Letters, 51(6) (2018) 849-859.

322.      Fluorimetric Determination of Nitrite in Water using a novel Fluorescence Dye

             Ramona Georgescu-State, Jacobus (Koos) Frederick van Staden and Luisa-Roxana Popescu-Mandoc

             Microchemical Journal, 137 (2018) 418-421.

323       Pattern recognition of 8-hydroxy-2′-deoxyguanosine in biological fluids

             Raluca-Ioana Stefan-van Staden, Liliana-Roxana Balahura, Livia Alexandra Gugoasa, Jacobus F. van Staden,

             Hassan Y. Aboul-Enein, Marcela-Corina Rosu and Stela Maria Pruneanu

             Analytical and Bioanalytical Chemistry, 410 (2018) 115–121. https://doi.org/10.1007/s00216-017-0698-7

INTERNATIONAL CONFERENCE CONTRIBUTIONS

2008

ORAL

1.          Fullerenes – New Chiral selectors for enantioanalysis.

             R.I. Stefan-van Staden.

             International Conference on Chemistry and Chemical Engineering. Romanian Chemical Society, Politehnica University of Timisoara, Timisoara, Romania. 28 – 30 May 2008.

2.          PATLAB. From test tube to Process Systems. The road ahead.

             J.F. van Staden.

             International Conference on Chemistry and Chemical Engineering. Romanian Chemical Society, Politehnica University of Timisoara, Timisoara, Romania. 28 – 30 May 2008.

3.          The importance and essentiality of real-time intelligent interactive monitoring and control in medical, pharmaceutical and clinical fields with PAT.

             J.F. van Staden, R.I. Stefan-van Staden and I. Balcu.

             3rd International Conference on Biomaterials and Medical Devices, BIOMMEDD’2008, Romanian and European Society for Biomaterials, Politehnica University of Bucharest, Romania.

             13 – 16 November 2008.

4.          New nanostructured materials based on porphyrins for the design of stochastic sensors.

             R.I. Stefan-van Staden, E. Fagadar-Cosma, J.F. van Staden, O. Radacina and S. Balasoiu.

             3rd International Conference on Biomaterials and Medical Devices, BIOMMEDD’2008, Romanian and European Society for Biomaterials, Politehnica University of Bucharest, Romania.

             13 – 16November 2008.

2009

ORAL

1.          Nanostructured glasses and powders based on hybrid silica materials incorporating 5,10,15-tris(3-hydroxy-phenyl)-20-(3,4-dimethoxy-phenyl)-porphyrin

             E. Fagadar-Cosma, C. Enache, D. Vlascici, Gh. Fagadar-Cosma, R.I. Stefan-van Staden, H. Stadler, J.F. van Staden.

             Nanotech Insight, 29th March – 2nd April 2009, Barcelona, Spain.

2.          Determination of free-L-T3 and free-L-T4 from blood using the immunosensors/sequential injection analysis system.

             RI van Staden, J.F. van Staden, H.Y. Aboul-Enein, G.L. Radu, N. Mirica,

             I. Balcu, M.C. Mirica

             Journées d’Electrochimie XIV-ème édition, 6 - 10 July 2009, Sinaia, Romania.

3.          Flow- or Non Flow-based, Unit operations, Micro- or/and Nanosensors: "Microfluidics", Real-time: Is a marriage with PAT always possible? The Reality and the Future.

             JF van Staden.

             Euroanalysis XV, Division of Analytical Chemistry (DAC) of the European Association of Chemical and Molecular Sciences (EuCheMS) and the Austrian Society for Analytical Chemistry (ASAC),              Innsbruck, Austria,

             6 - 10 September 2009.

4.          New stochastic microsensors based on nanostructured materials for molecular diagnosis.

             R.I. van Staden

             Euroanalysis XV, Division of Analytical Chemistry (DAC) of the European Association of Chemical and Molecular Sciences (EuCheMS) and the Austrian Society for Analytical Chemistry (ASAC),              Innsbruck, Austria,

             6 - 10 September 2009.

5.          Porphyrins in flow injection analysis

             J. F. van Staden

             IMA’2009. The 6th International Conference of  Instrumental Methods of Analysis. Modern Trends and Applications. Athens, Greece, 4 - 8 October 2009.

6.          New stochastic microsensors based on nanostructured manganese porphyrins for molecular diagnosis

             R. I. van Staden

             IMA’2009. The 6th International Conference of  Instrumental Methods of Analysis. Modern Trends and Applications. Athens, Greece, 4 - 8 October 2009.

7.          Sensors and biosensors for multicomponent analysis using flow systems

             J.F. van Staden, R. I. van Staden

             Modern Analytical Methods 2009 (dedicated to the 50th Anniversary of Nobel Prize in Polarography, J Heyrowsky). Prague, Czech Republic.

             9 - 13 December 2009.

POSTERS

1.          Porphyrins as new nanostructured materials for the design of stochastic sensors.

             R.I. Stefan-van Staden, E. Fagadar-Cosma, O. Radacina,  J.F. van Staden, S. Balasoiu, I. Balcu, M. Iorga.

             Nanotech Insight, 29th March – 2nd April 2009, Barcelona, Spain.

2.          Enantioanalysis of (-)butaclamol using vancomycin and teicopplanin as chiral selectors

             R.I. van Staden, J.F. van Staden, H.Y. Aboul-Enein, N. Mirica

             Euroanalysis XV, Division of Analytical Chemistry (DAC) of the European Association of Chemical and Molecular Sciences (EuCheMS) and the Austrian Society for Analytical Chemistry (ASAC),              Innsbruck, Austria, 6 - 10 September 2009.

3.          Modified diamond paste microelectrodes for the assay of ascorbic acid

             R.I. van Staden, S.C. Balasoiu, O.R. Vasile, J.F. van Staden, G.L. Radu

             Euroanalysis XV, Division of Analytical Chemistry (DAC) of the European Association of Chemical and Molecular Sciences (EuCheMS) and the Austrian Society for Analytical Chemistry (ASAC),              Innsbruck, Austria, 6 - 10 September 2009.

4.          Modified diamond paste microsensors for the assay of dopamine

             R.I. van Staden, S.C. Balasoiu, O.R. Vasile, J.F. van Staden, G.L. Radu

             IMA’2009. The 6th International Conference of  Instrumental Methods of Analysis. Modern Trends and Applications. Athens, Greece, 4 - 8 October 2009.

5.          Wireless sensors a tool for process control

             J.F. van Staden, R.I. van Staden, S.C. Balasoiu, O.R. Vasile,

             IMA’2009. The 6th International Conference of  Instrumental Methods of Analysis. Modern Trends and Applications. Athens, Greece, 4 - 8 October 2009.

6.          New nanostructured materials based electrochemical microsensors

             O.R. Vasile, R.I. van Staden, J.F. van Staden, S.C. Balasoiu, B.S. Vasile

             TNT 2009. 7-11 September, 2009 , Barcelona, Spain.

2010

ORAL

KEYNOTE PLENARY LECTURES

1.          The Importance and essentiality of interactive real-time intelligent monitoring and control in food processing and distribution with PAT  with food processing and distribution.

             J. F. van Staden.

             Challenges in Food Chemistry, Workshop, 28th May – 29th May 2010, Constanta, Romania.

2.          Stochastic sensors - a new tool for Food Analysis.

             R. I. van Staden.

             Challenges in Food Chemistry, Workshop, 28th May – 29th May 2010, Constanta, Romania.

3.          Stochastic Microsensors for Molecular Diagnosis.

             R. I. van Staden.

             IMCS’13, 13th International Meeting on Chemical Sensors, 11 – 14 July 2010, Perth, Australia.

4.          THE EVOLUTION OF ANALYTICAL CHEMISTRY FROM MANUAL PROCEDURES IN ROUTINE LABORATORIES TO FULLY

             AUTOMATED REAL-TIME INTERACTIVE MICRO  INFORMATION MANAGEMENT AND PROCESS CONTROL ON-SITE SYSTEMS.

             Prof Dr J. F. (Koos) van Staden.

             CMEQF 01-2010, Control and Metrology of Environmental Quality Factors, 23 – 27 November 2010, Iasi, Romania.

LECTURES

1.          DOT Sensors – New Tools for Biomedical Analysis.

             J. F. van Staden and R.I. Stefan-van Staden.

             IMCS’13, 13th International Meeting on Chemical Sensors, 11 – 14 July 2010, Perth, Australia.

2.          Carbon and Diamond Paste Microelectrodes based on Mn(III) Porphyrins for the Determination of Dopamine.

             J.F. van Staden, R.I. Stefan-van Staden, S.C. Balasoiu, and G.L. Radu.

             IMCS’13, 13th International Meeting on Chemical Sensors, 11 – 14 July 2010, Perth, Australia.

3.          DOT Sensors.

             J. F. van Staden.

             Diaspora Conference, 22nd – 24th September 2010, Bucharest, Romania.

4.          Diamond Paste based electrochemical (Bio)sensors.

             R. I. van Staden.

             Diaspora Conference, 22nd – 24th September 2010, Bucharest, Romania.

5.          COMBINED DOT SENSORS FOR FOOD ANALYSIS.

             J. F. van Staden and R. I. van Staden.

             AACD 2010, 7th Aegean Analytical Chemistry Days, 29th September – 3rd October 2010, Lesvos, Greece.

6.          MINICELLS FOR BIOMEDICAL INVESTIGATIONS.

             R. I. van Staden and J. F. van Staden.

             AACD 2010, 7th Aegean Analytical Chemistry Days, 29th September – 3rd October 2010, Lesvos, Greece.

POSTER

1.          Modified Carbon Paste Electrodes based on Porphyrin for the Enantioanalysis of S-Captopril.

             S. Balasoiu, R.I. van Staden, J.F. van Staden and G. L. Radu.

             Nanomeasures2010, 3rd – 4th June 2010, Krakow, Poland.

 

2011

 

ORAL

 

INVITED LECTURES

 

1.          Nanotechnology and flow systems.

             J F van Staden.

             ICFIA=2011. 17th International Conference on Flow Injection Analysis, including related techniques. Krakow,

             Poland. 3-8 July 2011.

 

LECTURES

 

1.          Nanotechnology in the flow domain of Process Analysis.

             J.F. van Staden, R.I. van Staden.

         Euroanalysis XVI, Division of Analytical Chemistry (DAC) of the European Association  of Chemical and Molecular Sciences  (EuCheMS) and the Austrian Society for Analytical Chemistry              (ASAC),  Belgrade, Serbia, 11 - 15 September 2011.

 

POSTERS

 

1.          Enantioanalysis of Pipecolic acid with stochastic and potentiometric microsensors.

             RI Stefan-van Staden, I Moldoveanu, DF Sava, C Kapnissi-Christodoulou, JF van Staden.

             Euroanalysis XVI, Division of Analytical Chemistry (DAC) of the European Association of Chemical and Molecular Sciences

             (EuCheMS) and the Austrian Society for Analytical Chemistry (ASAC),  Belgrade, Serbia, 11 - 15 September 2011.

 

2.          Amperometric Dot-sensors Based on Zinc Porphyrins for Sildenafil Citrate Determination.

             S. Balasoiu, R.I. van Staden, J.F. van Staden and G. L. Radu.

          Euroanalysis XVI, Division of Analytical Chemistry (DAC) of the European Association of Chemical and Molecular Sciences      (EuCheMS) and the Austrian Society for Analytical Chemistry              (ASAC),  Belgrade, Serbia, 11 - 15 September 2011.

 

2012

ORAL LECTURES

 

1.          Amperometric Dot-sensors Based on Zinc Porphyrins for Sildenafil Citrate Determination.

             J. F. van Staden and R.I. Stefan-van Staden.

             IMCS’14, 14th International Meeting on Chemical Sensors, 20-23 May 2012, Nuremberg,Germany.

INTERNATIONAL CONFERENCE CONTRIBUTIONS from 2012 -2017

387.      Amperometric Dot-Sensors based on Zinc Porphyrins for the Determination of Sildenafil Citrate.

             J. F. van Staden and R. I. van Staden.

             ICS 2012 The 14th International Meeting on Chemical Sensors, May 20 –23, 2012 Nuremberg, Germany (Oral presentation).

388.      New Stochastic Sensors for Biomedical Applications.

             R. I. van Staden, I. Moldoveanu, J. F. van Staden.

             IMCS 2012 The 14th International Meeting on Chemical Sensors, May 20 – 23, 2012 Nuremberg, Germany (Oral presentation).

390.      Nanotechnology and Multianalyte Platform Flow Systems.

             J. F. van Staden and R. I. van Staden.

             4th EuCheMS Chemistry Congress (EuCheMS 2012) 26-30 August 2012, Prague, Czech Republic (Oral presentation).

391.      Simultaneous neurotransmitters analysis using microelectrodes based on porphyrins.

             R. I. van Staden, I. Moldoveanu, J. F. van Staden.

             4th EuCheMS Chemistry Congress (EuCheMS 2012) 26-30 August 2012, Prague, Czech Republic (Oral presentation)

392.      Nanotechnology in the Flow Domain of Process Analysis.

             J. F. van Staden.

             1st International Conference on Analytical Chemistry. Analytical Chemistry for a Better Life, Targoviste, Romania, September

             18 - 21, 2012 (Invited Key note).

393.      Influence of the physical immobilization of dsDNA on the carbon based matrices of electrochemical sensors.

             L. A. Gugoasa, R. I. van Staden, A. A. Ciucu, J. F. van Staden

             1st International Conference on Analytical Chemistry. Analytical Chemistry for a Better Life, Targoviste, Romania, September

             18 - 21, 2012. (poster)

394.      New amperometric microsensors for the analysis of serotonin in urine samples.

             R. Georgescu, J. F. van Staden, I. Calinescu, R. I. van Staden

             1st International Conference on Analytical Chemistry. Analytical Chemistry for a Better Life, Targoviste, Romania, September

             18 - 21, 2012. (poster)

395.      Graphene based sensors for the assay of adenine, guanine and epinephrine

             R. Georgescu, J. F. van Staden, R. I. van Staden

             1st International Conference on Analytical Chemistry. Analytical Chemistry for a Better Life, Targoviste, Romania, September

             18 - 21, 2012. (poster)

396.      New amperometric microsensors for the analysis of serotonin in urine samples

             J. F. van Staden, R. Georgescu, R. I. van Staden.

             223rd ECS Meeting, May 12-16, 2013, Toronto, Canada (Oral presentation).

397.      Combined DOT sensors for food, pharmaceutical and biological analysis.

             J. F. van Staden, R. I. van Staden.

             245th ACS Meeting, April 7-11, 2013, New Orleans, USA (Oral presentation)

398.      Stochastic Sensors – New Tools for the Screening for Obesity.

             R. I. van Staden, L. A. Gugoasa, J. F. van Staden.

             223rd ECS Meeting, May 12-16, 2013, Toronto, Canada (Oral presentation)

399.      Graphene Based Microsensors for the Assay of Adenine, Guanine and Epinephrine.

             J. F. van Staden, R. Georgescu.

             224th Meeting of ECS, 27 October – 1 November, 2013, San Francisco, CA, USA (Invited keynote).

400.      Crisis in the Food Industry:- Is there a solution in real-time finding the source before, and  along the distribution line

             before the hazard strikes?

             J.F. van Staden.

             International Workshop Challenges in Food Chemistry, 31 May-1 June 2013, Constanta, Romania. (Invited Keynote)

401.      Graphene based dot microsensors for the assay of adenine, guanine and epinephrine.

             J.F. van Staden, R. Georgescu and R.I. Stefan-van Staden.

             224th ECS Meeting, 17 October-1 November 2013, San Francisco, USA. (Oral presentation)

402.      Combined dot sensors for food, pharmaceutical and biological analysis.

             J.F. van Staden and R.I. van Staden.

             224th ECS Meeting, 17 October-1 November 2013, San Francisco, USA. (Invited Keynote)

403.      Combined dot sensors in the domain of food, pharmaceutical and biological areas.

             J.F. van Staden and R.I. van Staden.

             225th ECS Meeting, 11 – 16 May 2014, Orlando, FL, USA. (Invited lecture)

404.      The Potential of Sensors and Biosensors for Integrated Process Control in Real-Time. Can They Survive the Environment?

             J.F. van Staden.

             225th ECS Meeting, 11 – 16 May 2014, Orlando, FL, USA. (Inivited lecture)

405.      Coated Tubular Ion-Selective Electrode Units in Process Systems.

             J.F. van Staden.

             225th ECS Meeting, 11 – 16 May 2014, Orlando, FL, USA. (Invited lecture)

406.      Can Sensors and Biosensors Survive the Demand of Factories of the Future for Process  Control in Real-Time?

             J.F. van Staden.

             International Conference on Analytical and Nanoanalytical Methods for Biomedical and Environmental

             Sciences “IC-ANMBES 2014”, Brasov, Romania, 13-15 June 2014 (Invited Plenary lecture)

407.      Novel Stochastic Sensor for Simultaneous Assay of  Neurotransmitters

             R.I. Stefan-van Staden, I. Moldoveanu, J.F van Staden

             International Conference on Analytical and Nanoanalytical Methods for Biomedical and Environmental

             Sciences “IC-ANMBES 2014”, Brasov, Romania, 13-15 June 2014 (Oral presentation)

408.      Screening Tools for Neuron Specific Enolase

             I.R. Comnea, R.I. Stefan-van Staden, J.F van Staden,C.S. Gavan (Oral presentation)

             International Conference on Analytical and Nanoanalytical Methods for Biomedical and Environmental Sciences “IC-ANMBES 2014”, Brasov, Romania, 13-15 June 2014 (Oral presentation)

409.      Evaluation of Amperometric Dot Microsensors for the Analysis of Folic Acid in Urine Sample, Pharmaceutical Tablets and Fruits Juice

             R. Georgescu,, J.F van Staden, R.I. Stefan-van Staden, I. Calinescu

             International Conference on Analytical and Nanoanalytical Methods for Biomedical and Environmental Sciences “IC-ANMBES   2014”, Brasov, Romania, 13-15 June 2014 (Oral presentation)

410.      Analytical continuous flow systems. Where two worlds collide! From gravimetry and test tubes to flow systems to FIA

             t o SIA to PAT and from Orsat to control room to PAT to TAP.

             J.F. van Staden.

             2nd International Conference on Analytical Chemistry (RO-ICAC'2014), 17 - 21 September 2014, Targoviste, Romania. (Invited   

Plenary lecture)

411.      Detection of folic acid from orange juice using amperometric dot microsensors based on  graphite modified with tetraamino and tetranitro phthalocyanines.

             R. Georgescu, J.F. van Staden, R.I. Stefan-van Staden, C. Boscornea.

              2nd International Conference on Analytical Chemistry (RO-ICAC'2014), 17 - 21 September 2014, Targoviste, Romania. (Oral presentation)

412.      Porphyrin based stochastic microsensors for the assay of dopamine, epinephrine, norepinephrine, serotonine, acetylcholine, gaba and glutamate.

             I. Moldoveanu, R.I. Stefan-van Staden, J.F. van Staden.

             2nd International Conference on Analytical Chemistry (RO-ICAC'2014), 17 - 21 September 2014, Targoviste, Romania. (Oral presentation)

413.      Platform based on microsensors used for the screening of her-1 in peritoneal fluid.

             I. Moldoveanu, R.I. Stefan-van Staden, J.F. van Staden, C. Stanciu-Gavan, C. Savlovschi.

             2nd International Conference on Analytical Chemistry (RO-ICAC'2014), 17 - 21 September 2014, Targoviste, Romania. (poster)

414.      Amperometric dot microsensors based on graphite and graphene modified with porphyrins for the analysis of folic acid from pharmaceutical tablets.

             R. Georgescu, J.F. van Staden, R.I. Stefan-van Staden, I. Calinescu.

             2nd International Conference on Analytical Chemistry (RO-ICAC'2014), 17 – 21 September 2014, Targoviste, Romania. (poster)

415.      Stochastic microsensors as screening tools for neuron specific enolase.

             I.R. Comnea, R.I. Stefan-van Staden, J.F. van Staden, C. Stanciu-Gavan.

             2nd International Conference on Analytical Chemistry (RO-ICAC'2014),17 - 21 September 2014, Targoviste, Romania. (poster)

416.      Stochastic Sensors Based on Diamond Paste for Screening of Biological Fluids for Neurotransmitters.

             R.I. Stefan-van Staden, I. Moldoveanu, J.F. van Staden.

             227th ECS Meeting, 24-28 May 2015, Chicago, IL, USA.

417.      ANALYTICAL CONTINUOUS FLOW SYSTEMS. WHERE TWO WORLDS COLLIDE! (1) FROM GRAVIMETRY AND TEST TUBES TO FIA TO SIA TO PAT AND (2) FROM ORSAT TO CONTROL ROOM TO

             PAT TO TAP.

             J.F. van Staden

             Euroanalysis XVIII, Division of Analytical Chemistry (DAC) of the European Association of Chemical and Molecular Sciences

             (EuCheMS),  Bordeaux, France, 6-10 September 2015. (Oral presentation)

418.      The Potential of Sensor Platforms for Dynamic Integrated Process Control in Real-Time. Are they Suitable to Function Properly in the Environment?

             Jacobus (Koos) van Staden (Invited talk)

             IC-ANMBES 2016, International Conference on Analytical and Nanoanalytical Methods for Biomedical and Environmental Sciences– June 29-July 1, 2016, Brasov, Romania.

419.      SENSOR (DETECTION) DEVICES AND PROCESS CONTROLLERS IN INTEGRATED REAL-TIME PROCESS CONTROL. DO THEY FULLFIL THE ACTUAL REAL-TIME ON-SITE?

             Jacobus F. van STADEN

             3rd International Conference on Analytical Chemistry August 28-31, 2016, Iasi, Romania (Invited talk)

420.      NEW NANOSTRUCTURED MATERIAL DETECTS 8-HYDROXY-2’ DEOXYGUANOSINE

             Roxana BALAHURA, Raluca-Ioana STEFAN-van STADEN, Livia Alexandra GUGOASA, Jacobus F. van STADEN,

             Hassan Y ABOUL-ENEIN.

             3rd International Conference on Analytical Chemistry August 28-31, 2016, Iasi, Romania (Oral presentation)

421.      DETERMINATION OF DOPAMINE USING THE ALKALINE LUMINOL-HYDROGEN PEROXIDE SYSTEM FOR SEQUENTIAL INJECTION – ZONE FLUIDICS ANALYSIS.

             Ramona GEORGESCU-STATE, Jacobus Frederick van STADEN.

             3rd International Conference on Analytical Chemistry August 28-31, 2016, Iasi, Romania (Oral presentation)

422.      Reliable, sustainable, sufficient and convenient devices and/or systems for real-time interactive monitoring and control.

             Jacobus (Koos) F van Staden (Invited talk)

             41st ARA, Congress of the American Romanian Academy of Arts and Sciences, 2-5 August 2017, PALACE, Sinaia. Romania.

423.      Determination of Lead in Water Using Modified Electrodes Based on Phthalocyanine

             Georgiana-Luiza Arnold, Jacobus (Koos) Frederick van Staden, Ramona Georgescu-State, Luisa-Roxana Popescu-Mandoc

             41st ARA, Congress of the American Romanian Academy of Arts and Sciences, 2-5 August 2017,

             PALACE, Sinaia. Romania. (Poster)

424.      New Nanostructured Materials Detect Dopamine in Biological Fluids

             Raluca-Ioana Stefan-van Staden, Liliana-Roxana Balahura, Alexandra Oprisanu-Vulpe, Livia Alexandra Gugoasa,

             Jacobus F. van Staden, Eleonora-Mihaela Ungureanu, Crina Socaci

             41st ARA, Congress of the American Romanian Academy of Arts and Sciences, 2-5 August 2017, PALACE, Sinaia. Romania

            (Poster)

425.      A Fluorimetric Method for the Determination of Nitrite in Water

             Ramona Georgescu-State, Jacobus (Koos) Frederick van Staden, and Georgiana-Luiza Arnold, Luisa-Roxana Popescu-Mandoc

             41st ARA, Congress of the American Romanian Academy of Arts and Sciences, 2-5 August 2017,

             PALACE, Sinaia. Romania. (Poster)

426.      Heavy Metals Detections Using Stochastic Microsensors

             Ioana-Georgiana Lazar, Raluca-Ioana Stefan-van Staden, Livia Alexandra Gugoasa, Jacobus Frederick van Staden.

             41st ARA, Congress of the American Romanian Academy of Arts and Sciences, 2-5 August 2017,

             PALACE, Sinaia. Romania. (Poster)

427.      Microbiological Study: Effect Of Pinaceae and Lamiaceae Essential Oils on 3 Bacterial Germs

             Ioana Adina Oancea, Jacobus (Koos) Frederick van Staden, Elena Oancea, Eleonora-Mihaela Ungureanu

             41st ARA, Congress of the American Romanian Academy of Arts and Sciences, 2-5 August 2017,

             PALACE, Sinaia. Romania. (Poster)

428.      Molecular Determination of Pyruvic Acid in Diabetic Patients by Using Stochastic Mode

             Raluca-Ioana Stefan-van Staden, Ioana Popa-Tudor, Livia Alexandra Gugoasa, Jacobus Frederick van-Staden,

             Constantin Ionescu-Targoviste

             41st ARA, Congress of the American Romanian Academy of Arts and Sciences, 2-5 August 2017,

             PALACE, Sinaia. Romania. (Poster)

429.      Pattern Recognition of Cu(II), Cd(II), Hg(II), and Pb(II) in Waste Water Samples

             Jacobus (Koos) Frederick van Staden

             EUROANALYSIS2017, Stockholm, Sweden. 28 August – 1 September 2017 (Oral presentation)

430.      Electrochemical detection of Ursolic Acid from one original dermato-cosmetic plant extract with regenerative effect on human skin, using modified sensors

             Ioana Adina Oancea, Jacobus Frederick van Staden, Elena Oancea, Eleonora-Mihaela Ungureanu

             20th Romanian International Conference on Chemistry and Chemical Engineering (RICCCE2017), Polana, Brasov, Romania,

             6-9 September 2017 (Poster).

PATENTS

2009

1.       STOC-µSENS-CMD

          Raluca-Ioana van Staden, Jacobus Frederick van Staden

EARLY DETECTION OF CANCER –TIME IS LIFE.

        Website link: http://vimeo.com/38098247

1.          Procedure for the design of a sensor for early diagnosis of cancer. STOC-µSENS-CMD, R I van Staden and J F van Staden,

             B1125050/2010, OSIM/Romania

2.          Enantioselective DOT Sensor and procedure for its construction, R I van Staden and J F van Staden, A/01120/2010,

             OSIM/Romania

3.          Sistem de Scanare pentru analize biomedicale, R I van Staden and J F van Staden, A/1013753/2016, OSIM/Romania

AWARDS

2008

NATIONAL

1.       Raluca-Ioana van Staden. Gold Medal and Diploma of Excellence ((with the contribution of Dr Eugenia-Lenuta

          Fagadar-Cosma (Institute of Chemistry Timisoara) regarding the supplying of the porphyrins for the design

          of the sensors on Contract nr D1 1055/2007)) for a patent on stochastic sensors at the 2nd International

          Congress of the Researchers and Inventors from Romania, 11 - 12 December 2008, Bucharest, Romania.

2009

1.       Raluca-Ioana van Staden was awarded the Second (2nd) Prize in a Gala of Prizes for Education, Section Research,

          on 29 October 2009 in Bucharest, Romania organized by the Foundation Dinu Patriciu.

NATIONAL

1.       Raluca-Ioana van Staden. Pro Invent Medal and Diploma of Excellence, and Diploma of Excellence of the Society

          of Inventors from Romania, ((with the contribution of Dr Eugenia-Lenuta Fagadar-Cosma (Institute of

          Chemistry Timisoara) regarding the supplying of the porphyrins for the design of the sensors on Contract

          nr D1 1055/2007)) for a patent on stochastic sensors at the Pro Invent, 24 - 27 March 2009, Cluj-Napoca, Romania.

2.       Raluca-Ioana van Staden and Jacobus Frederick van Staden: Gold Medal and Award Extraordinary Recognition

          of the Union of Croatian Innovators for a patent with title: “STOC-µSENS-CMD” – regarding cancer diagnosis

          at molecular level, before the patient is clinically ill, at Inventika, 28 - 31 October 2009, Bucharest, Romania.

INTERNATIONAL

1.       Raluca-Ioana van Staden. Gold Medal, and Arca Prize of the Society of Inventors from Croatia,

          ((with the contribution of Dr Eugenia-Lenuta Fagadar-Cosma (Institute of Chemistry Timisoara) regarding the

          supplying of the porphyrins for the design of the sensors on Contract nr D1 1055/2007)) for a patent on

          stochastic sensors at the 37eme Salon International des Inventions des Techniques et Produit Nouveaux,

          1-5 April 2009, Geneve, Switzerland.

2.       Raluca-Ioana van Staden. Gold Medal, and the Prize of the Polish Federation of Engineering Association - NOT, ((with the contribution of

          Dr Eugenia-Lenuta Fagadar-Cosma (Institute of Chemistry Timisoara) regarding the supplying of the porphyrins for the design of the sensors on

          Contract nr D1 1055/2007)) for a patent on stochastic sensors at the International Warsaw Invention Show, IWIS 2009, 1-3 June 2009, Warsaw, Poland.

  

3.       Raluca-Ioana van Staden and Jacobus Frederick van Staden: Gold Medal and Premiul Technopol Moscova for a patent with title:

         “STOC-µSENS-CMD” – regarding cancer diagnosis at molecular level, before the patient is clinically ill, at the IXth Moscow International Salon

          of Innovations and Investments, 26 - 29 August 2009,  Moscow, Russian Federation.

4.       Raluca-Ioana van Staden and Jacobus Frederick van Staden: Silver Bord for the patent with the title: “STOC-µSENS-CMD” – regarding cancer diagnosis

          at molecular level, before the patient is clinically ill, at ARCA 2009, 15-19 September 2009, Zagreb, Croatia

5.       Raluca-Ioana van Staden and Jacobus Frederick van Staden: Gold Medal with mention and AGEPI Cup of the Agency of the Intelectual Property

          from Moldova for the patent: “STOC-µSENS-CMD” – regarding cancer diagnosis at molecular level, before the patient is clinically ill,

           at EUREKA 2009, 19-21 November 2009,  Brussels, Belgium.

2010

NATIONAL

1.      Raluca-Ioana van Staden and Jacobus Frederick van Staden: Gold Medal with special mention and Diploma of Excellence for the patent:

         “STOC-µSENS-CMD” – regarding cancer diagnosis at molecular level, before the patient is clinically ill, at PRO INVENT 2010, 16-19 March 2010,

          Cluj-Napoca, Romania.

2.      Prof Dr Jacobus Frederick van Staden: Gold Medal and Diploma for the Exceptional Contribution at the International PRO INVENT 2010,

          16-19 March 2010,  Cluj-Napoca, Romania.

INTERNATIONAL

1.       Raluca-Ioana van Staden was awarded the top Geneva Gold Trophy from the World Intellectual Property Organization as the best

          "Best Woman Inventor" for the patent: “STOC-µSENS-CMD” – Raluca-Ioana van Staden and Jacobus Frederick van Staden regarding

          microsensors for cancer diagnosis at molecular level in 6 minutes, before the patient is clinically ill, 38eme Salon International des

          Inventions des Techniques et Produit Nouveaux, 20-25 April 2010, Geneve, Switzerland.

2.       Raluca-Ioana van Staden and Jacobus Frederick van Staden were awarded the Gold Medal with special mention and Diploma of Excellence with

          special congratulations from the Jury as well as a special prize in the form of the L’AGEPI medal and diploma from the Republic of Moldova

          for the patent: “STOC-µSENS-CMD” – regarding microsensors for cancer diagnosis at molecular level in 6 minutes, before the patient is clinically ill,

          38eme Salon International des Inventions des Techniques et Produit Nouveaux, 20-25 April 2010, Geneve, Switzerland.

PATLAB also fulfil its mission with a steadily increase in the number of young researchers/post graduate students and currently the people (researchers) actively involved  in the research teams of PATLAB including the young researchers/post graduates increased to a total of 25 including 9 young researchers with PhD-qualifications, 2 Post Doc students; and 11 students that are busy with research for PhD and 2 MSc-students at PATLAB from the POLITEHNICA  University of Bucharest  and from the “Politehnica” University of Timisoara.

We also have an active role in the international scientific community with J. (Koos) F. van Staden serving on the International Advisory Board of Analytical Letters and Journal of Flow Injection Analysis and R. (Raluca) I. van Staden on the International Advisory Board of Preparative Biochemistry and Biotechnology, Sensor Letters and Sensors & Transducers Journal. Both of us are also in a constant process of receiving and refereeing manuscripts from various international journals. J. (Koos) F. van Staden serves on the Steering and Scientific Committees of International Meetings. Both Koos and Raluca van Staden is active members of the Division of Analytical Chemistry (DAC) of the European Association of Chemical and Molecular Sciences (EuCheMS) and both are also members of the European Association of Chemical and Molecular Sciences (EuCheMS), of The Electrochemical Society (ECS) and of the American Chemical Society (ACS). Raluca van Staden is the Chair of Romanian International Chapter of ACS in Romania.

Professor Dr. Jacobus Frederick van Staden, Professor Emeritus of the University of Pretoria, South Africa and Director of PATLAB, Bucharest, Romania was the Honorary President and Prof Dr Eng. Radu Munteanu, Rector of the Technical University of Cluj-Napoca, Romania the President of the Jury on the occasion of the eighth edition of the International Exhibition of Research, Innovation and Inventions, “PRO INVENT 2010”, organized by the Technical University in collaboration with the Chamber of Commerce and Industry of Romania and the Union Society of Inventors Universities in Cluj,  between 16-19 March 2010 in  Cluj-Napoca, Romania. Prof Koos van Staden was involved in various projects with various process industries for example with SASOL, pharmaceutical companies, Be Beers, Element 6, Anglo American, Amplats, MINTEK, National Water Research Commission etc in RSA and international where he developed expertise with involvement in Process Intensification, Chemical, Electrochemical and Optical Sensors, Catalysis, Process Technologies, Catalytic Membrane (Bio)Reactors, Automotive Battery Research etc. and he served as Project Technical Advisor in 13 projects for the European Commission since 2009 up to 2016 where he was also involved as rapporteur, independent observer, evaluator and as technical scientific reviewer. During this period he also becomes an active member of SUSCHEM from the European Commission.

Services offered to end-users:

1. Process analysis in the fields of UV/Vis, Fluorescence, Chemiluminescence, Electrochemistry

2. Process Platform Systems with automation, monitoring and control

3. Analytical Sensor Electrochemical and Photonic Platforms for fast interactive control.

4. Surface Analysis,

5. Study of biochemical reactions,

6. Enzymatic Kinetics,

7. Corrosion,

8. Deposition and analysis of thin layers

THE PRICE OF THE SERVICE WILL BE ESTABLISHED ACCORDINGLY WITH THE SAMPLE AND/OR THE METHOD USED.

The application areas of the new SPR are:

•  Biosensors (in combination with amperometry/impedance spectroscopy)
• Conducting polymers
• Enzymes
• Membrane proteins
• DNA - DNA interactions
• Protein - virus interactions
• Peptide - antibody interactions

The application areas of the new SECM370 Scanning Electrochemical Microscope system are:

• Studying flow through membranes
• Monitoring biologic activity
• Determining kinetic parameters
• Imaging immobilized enzymes
• Monitoring living cells
• Liquid-liquid interfaces
• Chemical imaging of biosystems
• Materials for fuel cell research
• Localized ISE
• Surface modification
• Corrosion science

PATLAB-Flyer:-

The following is the current flyer distributed by PATLAB.

 

WELCOME to:-

PATLAB

(www.patlab.ro)

the

 PROCESS ANALYTICAL TECHNOLOGY LABORATORY

in BUCHAREST

Of

 

the National Institute of Research and Development for Electrochemistry and Condensed Matter

ESTABLISHMENT OF A LABORATORY OF PROCESS ANALYTICAL TECHNOLOGY.

PATLAB

Project financed by contract 120 CP/I/14.09.2007

From PN II, Capacity, Module 1

ESTABLISHMENT OF A LABORATORY OF PROCESS ANALYTICAL TECHNOLOGY. EXTENSION1.

PATLAB-EXTENSION1.

Project financed by contract 172 CP/I/02.09.2008

From PN II, Capacity, Module 1

Process Analytical Technology (PAT) is the application of Analytical Science in its broadest sense to monitor and control any activity also called operating systems (or processes) as a global entity (in totality) in real-time.

Micro Process Analytical Technology (MPAT) implies the study and application of PAT with all the available sources and modern microsystems technology.

Nano Process Analytical Technology (NPAT) implies the study and application of PAT with all the available sources and modern technology on a nano- and even atomic scale.

VISION:- The primary vision is to use PATLAB as a basis and source to supply the necessary skills and education with high quality research and innovation to serve as a catalyst for cost effective dynamic actively driven industries to improve the quality of life and wealth in a sustainable environment.  

MISSION: Research and development in flow-based and non-flow-based systems using PAT and NPAT to create smart intelligent interactive process equipment with highly intelligent interactive built in monitoring and PID control devices to ensure either single-point or multi-point multi-species real-time measurements.

STRATEGY: The strategy of PATLAB, aligned to the national strategy of the R-D-I domain, is to integrate successfully with high level advanced competitive modern instrumentation for research-development as a research laboratory of excellent international status and competence into the new European and national research networks. This should be done in co-operation formed by institutes, universities and economic agents for approach of technological and scientific development programs, that will lead to a social and economical development of our country.

EDUCATION AND TRAINING: It is also my ambition to deliver highly and fully educated specialized young researchers with the necessary skills and dedication to our country to supervise and to keep these systems at end-users in tact and in full operation. Master- and PhD-students (with universities)

should feel welcome to use PATLAB with well-equipped facilities as base for their studies to become so well-trained that their expertise should be wanted where-ever they wanted to go, be able to become entrepreneurs to enhance economical development of production and research human potential.

RESEARCH DOMAINS: Process and Nanoprocess analytical technology (PAT and NPAT (on-line, in-line and at-line) for real-time monitoring and small scale synthesis (microreactors and bioreactors) in different fields for example of industrial processes, pharmaceutical manufacturing, agricultural production, health care and medical diagnostics, environmental pollution, leather, paper, ceramic, paints, coatings, textile industries. Research on materials for renewable energy. Research on nanostructures on nano- and atomic scale with high resolution AFM/STM, mini-electrochemical, mini-bioelectrochemical and mini-spectroscopic devices. In this regard, new technologies (including new theoretical foundations and nanotechnologies) on continuous flow, flow injection, sequential injection, sequential flow injection, microfluidics, rotating disc nanotechnology and dot and fiber optic sensors, separation techniques, chromatography (ionic and liquid), capillary electrophoresis, with spectrometric, chemiluminescence, sensors and biosensors as detectors will be developed and implemented

RESEARCH PROJECTS AWARDED THROUGH COMPETITION:-

from the National Plan for Research, Development and Innovation – PN II – Framework of the National Authority for Scientific Research:

CAPACITY PROGRAM – 2007 – Module 1 - PI

Domain 7. Materials, processes and Innovative Production.

ESTABLISHMENT OF A LABORATORY OF PROCESS ANALYTICAL TECHNOLOGY. PATLAB.

CAPACITY PROGRAM – 2008 – Module 1 – P1

Domain 7. Materials, processes and Innovative Production.

ESTABLISHMENT OF A LABORATORY OF PROCESS ANALYTICAL TECHNOLOGY. EXTENSION1. PATLAB-EXTENSION1.

from the National Plan for Research, Development and Innovation – PN II – Framework of the National University Research Council:

IDEA PROGRAM – 2008

Domain 10. Chemical and Process Engineering.

DOT SENSORS. A NEW CONCEPT IN SENSORS TECHNOLOGY.

CURRENT INSTRUMENTATION

1. FLOPRO-FLOW PROCESS RESEARCH ANALYZER.

FlowPro process analyzer configured with two milliGAT pumps, 2 multiposition selection valves, LED-based photometer, heated reactor, process robust computer and software

2. MINI-FLOPRO-ZONE FLUIDICS RESEARCH PROCESS ANALYZER WITH UV/Vis   DETECTION.

Mini-FloPro equipped with milliGAT pump, 2 selection valves, heated reactor and plumbed for zone fluidics equipped to study a variety of chemistries. Ocean Optics multi wavelength spectrometer for UV/vis detection. Laptop PC and process development software.

3. MINI-FLOPRO-ZONE FLUIDICS RESEARCH PROCESS ANALYZER. POTENTIOSTAT  FOR AMPEROMETRIC DETECTION

Mini-FloPro equipped with milliGAT pump, 2 selection valves, heated reactor and plumbed for zone fluidics equipped to study a variety of chemistries. Bioanalytical Petit Ampere potentiostat for amperometric detection. Laptop PC and process development software.

4. MINI-FLOPRO-ZONE FLUIDICS RESEARCH PROCESS ANALYZER WITH  FLUORESCENCE DETECTION

Mini-FloPro equipped with milliGAT pump, 2 selection valves, heated reactor and plumbed for zone fluidics equipped to study a variety of chemistries. Ocean Optics detector for fluorescence detection. Laptop PC and process development software.

5. MINI-FLOWPRO-ZONE FLUIDICS RESEARCH PROCESS ANALYZER WITH CHEMILUMINESCENCE DETECTION

Mini-FloPro equipped with milliGAT pump, 2 selection valves, heated reactor and plumbed for zone fluidics equipped to study a variety of chemistries. Global FIA FireFly detector for chemiluminescence detection. Laptop PC and process development software.

6. QE65000 SCIENTIFIC-GRADE SPECTROMETER FOR FLUORESCENCE DETECTION.

QE65000 Scientific-grade Spectrometer, fluorescence setup, PX-2 Pulsed Xenon Lamp as an excitation source, Hamamatsu FFT-CCD detector, detector range 200-1100 nm, Full scans to memory every 7 ms with USB 2.0 port as data transfer rate, Quantum Efficiency to 90%, Optical Fiber Bundles, Computer and software.

7. HR4000 HIGH-RESOLUTION SPECTROMETER.

HR4000 high-resolution spectrometer, UV/Vis through Shortwave NIR setup, Balanced Deuterium Tungsten Source, 3648-element CCD-array detector from Toshiba that enables optical resolution as precise as 0.02 nm (FWHM), detector range 200-1100 nm, Full scans to memory every 4 ms with USB 2.0 port as data transfer rate, Optical Fiber Bundles, Computer and software.

8. UNISCAN PG580 MINI-POTENTIOSTATS (3 UNITS) METROHM AUTOLAB POTENTIOSTATS (3 UNITS) (PGSTAT12, PGSTAT302N and PGSTAT100)

All units suitable for Cyclic and linear voltammetry, Square wave voltammetry, Normal and differential pulse voltammetry Chronoamperometry and chronopotentiometry with micro- and nanosensors, able to bundle up to 5 working electrodes-multiplexed.

9. AGILENT 5500 SERIES ATOMIC FORCE  MICROSCOPY (AFM)/SCANNING  PROBE MICROSCOPY (SPM)

Agilent 5500 ideal multiple-user research system for atomic force microscopy (AFM) and scanning probe microscopy (SPM) with electrochemical scanning microprobe microscopy (EC-SPM) to study the behaviour and kinetics of electrochemical micro- and nanoprobes in real time, Pico-TREC for simultaneous topography and recognition imaging with SPM for mapping target molecules on a sampling surface ideally suited for nanoelectrode sensor structuring and modifying, lithography and nanomanipulation with micro machining through force variations, nano patterning via probe bias and electrochemical etching, nano writing and nano modification via surface potential controlled deposition.

10. SHIMADZU 3600 DOUBLE BEAM UV-VIS-NIR SPECTROPHOTOMETER

High-resolution research spectrometer Wavelength range 185 – 3300 nm, Equipped with 3 detectors: a PMT detector (photomultiplier tube) for the ultraviolet and visible regions, and InGaAs and PbS detectors for near infrared region. InGaAs detector bridges the gap between the PMT - PbS switching wavelength where sensitivity is typically low to ensure high sensitivity over the entire measurement wavelength range with <0.00003 Abs noise at 1500 nm.

11. CYBERSCAN PCD 6500 pH/ION/CONDUCTIVITY/DO MULTIMETER.

Cyberscan PCD 6500  pH/Ion/Conductivity/Dissolved Oxygen multimeter measures and views up to four parameters at the same time with no cross-channel reference. A CE-Driven Full-Colour Touchscreen 21 CFR Part 11-compliant Bench meter with real-time on-screen multichannel, single channel or graphical analysis functions to give quick, convenient analysis of data with advanced, extensive communication capabilities with USB.

12. AUTOLAB ESPRIT SURFACE PLASMA RESONANCE INSTRUMENT.

The Autolab Surface Plasma Resonance (SPR) instrumentation helps the scientist to analyze bi-molecular interactions in real time, without labeling requirements. The Autolab ESPRIT allows the user to perform high-througput SPR experiments using a fully automated system including a reference channel for temperature and non-specific binding compensation. The Autolab Esprit is a unique double channel Surface Plasma Resonance (SPR) instrument with an autosampler incorporated with a normal standard cuvette for all Surface Plasma Resonance (SPR) measurements where biomolecular interactions are studied and a normal cuvette is standard supplied for all SPR measurements where biomolecular interactions are studied. The optional electrochemical cuvette allows measurements on a 3-electrode system: a fixed contact point to the gold layer of the sensor disk, the gold operates as working electrode, replaceable Ag/AgCl reference electrode and a fixed Platinum counter electrode.

13.  SECM370 SCANNING ELECTROCHEMICAL MICROSCOPE SYSTEM.

The SECM370 is a precision scanning micro-electrode system, which can be used to monitor (or impose) current flowing between a micro-electrode and a specimen surface in solution at extremely high spatial resolutions. It can be used to examine, analyse or alter the surface chemistry of a sample in solution. This equipment has many potential applications in the study of fundamentals of surface reactions for example in flow through membranes, chemical imaging of biosystems, corrosion science, or the study of enzyme stabilization. The SECM370 system includes a precision dual potentiostat system, allowing full control and measurement of electrochemical processes at the micro-electrode tip and substrate independently.

14. QEPRO-Raman Scientific-grade Spectroscopy

The QEPRO-Raman Scientific-grade Spectrometer is a preconfigured combination of detector, optical bench, electronics, probe and laser technologies that provide users with a remarkably sensitive system for demanding low-light level Raman spectroscopy. The QE65000-Raman can achieve up to 90% quantum efficiency with high signal-to-noise and rapid signal processing speed.

   15. PORTABLE PINPOINTER RAMAN INSTRUMENT

PATLAB is equipped with a PinPointer instrument that packs a full-featured Raman system in a true hand-held unit. This is the next generation of the portable Raman spectrometer that was featured in an episode of CSI Miami and a cave exploring documentary by NASA scientists on the National Geographic Channel. The unit is controlled by a miniature Windows computer and features easy-to-use ID-find™ software that provides one-touch identification of unknown substances by immediate comparison of a measured spectrum to the on-board Raman spectral library.

  16. SUPER-FAST OCEAN FX SPECTROMETER

PATLAB has a SUPER-FAST OCEAN FX SPECTROMETER with High Sensitivity, Fast Acquisition Speed and Enhanced Communications. The Ocean FX is a versatile spectrometer distinguished by acquisition speed up to 4,500 scans per second, onboard processing for improved SNR and reduced data transfer time, and robust communications via USB, SPI, Gigabit Ethernet and Wi-Fi. Ocean FX is an excellent choice for high-speed process applications, measurement of fast events, and reaction monitoring.

CONTACT:- PATLAB. BUCHAREST.

Prof Dr.CS I. J (Koos) F van Staden,

PATLAB,

Process Analytical Technology Laboratory,

Splaiul Independentei St., No 202,

Bucharest. 060021.

ROMANIA.

Mobile: +4 074 169 5743  or +4 074 943 2360 or +4 074 813 7871

E-mail: koosvanstaden2012@yahoo.com or koosvanstaden@patlab.ro